Expectant father Peter Highman (Robert Downey Jr.) is flying home from Atlanta in order to bear witness to the birth of his first child. When he encounters Ethan Tremblay (Zach Galifianakis), a socially retarded wannabe actor at the airport, things get off on the wrong foot when they inadvertently exchange bags and Peter gets stopped in security for carrying drug paraphernalia. Sadly, that's the highlight of his trip because he's soon kicked off the plane, put on the no-fly list, and is forced to take a cross-country car trip with the man responsible for his troubles.
My expectations were pretty low going into this, and for good reason. The trailers made it look like a complete rip-off of Planes, Trains, and Automobiles, and unfortunately it isn't as funny as the classic John Candy/Steve Martin movie. The first act sets up the scenario pretty well, but then it quickly falls apart when the two protagonists hit the road.